Bronchopulmonary dysplasia (BPD) commonly develops in premature infants. An improved understanding of the pathophysiology of BPD requires better models. In this study, neonatal FVB/N mice were exposed to room air or 85% oxygen for 28 days. Neonatal hyperoxia resulted in decreased alveolar septation, increased terminal air space size, and increased lung fibrosis. These changes were evident after 7 days and more pronounced by 28 days. Decreased alveolarization was preceded by decreased proliferation of lung cells. After 3 days of hyperoxia, cell proliferation was decreased compared with room air littermates. Cell proliferation continued to be decreased in the first 2 wk but normalized by 4 wk. Hyperoxia caused an increased number of inflammatory cells in lung tissue and in lung lavage fluid. Analysis of lung tissue RNA by RT-PCR showed that hyperoxia increased expression of the proinflammatory cytokines interleukin-1alpha and macrophage inflammatory protein-1alpha. Prolonged neonatal hyperoxia caused functional changes, decreasing lung volume and pulmonary compliance. We conclude that prolonged exposure of neonatal mice to hyperoxia creates a lesion that is very similar to human BPD and suggests that altered cell proliferation may be important in the pathogenesis of chronic neonatal lung disease.
As a part of this research study for side effects of metformin use in diabetics, there were total 144 patients who participated in the study. They were closely monitored for nutritional status and various biophysical measurements. 37% participants of the study between age 30-90 years were diagnosed with vitamin b12 deficiency. Deficiency number was on the higher side in women with more than 30% women were found with extremely low Vitamin B12 levels. The research has suggested efficacy trials for Vitamin B12 supplementation in type 2 diabetes patients.
Union campaign to seat workers
South Korea’s largest union umbrella group has launched a campaign to make discount stores and other workplaces provide chairs for workers who are needlessly forced to stand. The Korean Confederation of Trade Unions (KCTU) said the move is to prevent standing-related health problems.
Korea Times • Hazards guide to workplace standing hazards • Risks 349
Hazards news, 29 March 2008