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During conventional pharmacologic dose corticosteroid therapy, ACTH production is inhibited with subsequent suppression of cortisol production by the adrenal cortex. Recovery time for normal HPA activity is variable depending upon the dose and duration of treatment. During this time the patient is vulnerable to any stressful situation. Although it has been shown that there is considerably less adrenal suppression following a single morning dose of prednisolone (10 mg) as opposed to a quarter of that dose administered every six hours, there is evidence that some suppressive effect on adrenal activity may be carried over into the following day when pharmacologic doses are used. Further, it has been shown that a single dose of certain corticosteroids will produce adrenal cortical suppression for two or more days. Other corticoids, including methylprednisolone, hydrocortisone, prednisone, and prednisolone, are considered to be short acting (producing adrenal cortical suppression for 1¼ to 1½ days following a single dose) and thus are recommended for alternate day therapy.

If you want to reduce body fat in the most effective and safest manner possible, you will need a cutting stack from Crazy-. This will facilitate weight loss while preserving lean muscle mass. You need to diet to lose weight. The main challenge of dieting is that it makes your body activate starvation mode. In this mode, there is metabolism of lean muscle instead of fat reserves. This is simply counterproductive since muscles help in burning calories. With a cutting stack, the body will burn fat instead of muscles when you are dieting. This will make you lose fat while being able to preserve your hard-earned muscle gains.

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Low levels of serotonin , a neurotransmitter in the brain, have been linked to depression . High levels of estrogen, as in first-generation COCPs, and progestin, as in some progestin-only contraceptives, have been shown to lower the brain serotonin levels by increasing the concentration of a brain enzyme that reduces serotonin. This observation, along with some small research studies [66] have inspired speculation that the pill causes depression. In 2016, a large Danish study of one million women showed that use of COCPs, especially among adolescents, was associated with a statistically significantly increased risk of subsequent depression, although the sizes of the effects are small (for example, % of the women who took any form of oral birth control were prescribed anti-depressants for the first time, compared to % of women in the control group). [67]

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Low levels of serotonin , a neurotransmitter in the brain, have been linked to depression . High levels of estrogen, as in first-generation COCPs, and progestin, as in some progestin-only contraceptives, have been shown to lower the brain serotonin levels by increasing the concentration of a brain enzyme that reduces serotonin. This observation, along with some small research studies [66] have inspired speculation that the pill causes depression. In 2016, a large Danish study of one million women showed that use of COCPs, especially among adolescents, was associated with a statistically significantly increased risk of subsequent depression, although the sizes of the effects are small (for example, % of the women who took any form of oral birth control were prescribed anti-depressants for the first time, compared to % of women in the control group). [67]

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