Overview of steroidogenic enzymes in the pathway from cholesterol to active steroid hormones

SOX-9 also plays a pivotal role in male sexual development; by working with Sf1, SOX-9 can produce AMH in Sertoli cells to inhibit the creation of a female reproductive system. [7] It also interacts with a few other genes to promote the development of male sexual organs. The process starts when the transcription factor Testis determining factor (encoded by the sex-determining region SRY of the Y chromosome ) activates SOX-9 activity by binding to an enhancer sequence upstream of the gene. [8] Next, Sox9 activates FGF9 and forms feedforward loops with FGF9 [9] and PGD2 . [8] These loops are important for producing SOX-9; without these loops, SOX-9 would run out and the development of a female would almost certainly ensue. Activation of FGF9 by SOX-9 starts vital processes in male development, such as the creation of testis cords and the multiplication of Sertoli cells . [9] The association of SOX-9 and Dax1 actually creates Sertoli cells, another vital process in male development. [10]

Dehydroepiandrosterone comes into subsequent oxidative transformation with production of 16Alpha-hydroxydehydroepiandrosterone . This oxidation is catalyzed by Cytochrome P450, family 3, subfamily A, polypeptide 7 ( CYP3A7) [10] , [11] , [12] and Cytochrome P450, family 3, subfamily A, polypeptide 4 ( CYP3A4) [13] , [10] , [11] . Oxidative metabolite of this reaction as well as Dehydroepiandrosterone can be further sulfated by steroid sulfatase (microsomal), isozyme S ( STS ) [14] , [15] , [16] , [15] , [14] . Dehydroepiandrosterone and Dehydroepiandrosterone sulfate can be transformed into other compounds with hormonal activity, Androstendiol and Androstendiol sulfate , respectively. These two reactions are catalyzed by Hydroxysteroid (17-beta) dehydrogenase 1 ( HSD17B1) [17] , [18] , [17] , [18] , Hydroxysteroid (17-beta) dehydrogenase 2 ( HSD17B2) [19] , [20] , [20] , [21] , and Hydroxysteroid (17-beta) dehydrogenase 7 ( HSD17B7 ) [22] , [23] , [23] , [24] .

Overview of steroidogenic enzymes in the pathway from cholesterol to active steroid hormones

overview of steroidogenic enzymes in the pathway from cholesterol to active steroid hormones

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overview of steroidogenic enzymes in the pathway from cholesterol to active steroid hormonesoverview of steroidogenic enzymes in the pathway from cholesterol to active steroid hormonesoverview of steroidogenic enzymes in the pathway from cholesterol to active steroid hormonesoverview of steroidogenic enzymes in the pathway from cholesterol to active steroid hormonesoverview of steroidogenic enzymes in the pathway from cholesterol to active steroid hormones

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