Topical ophthalmic steroid ointment

Pregnancy Category C : Reproduction studies performed with nepafenac in rabbits and rats at oral doses up to 10 mg/kg/day have revealed no evidence of teratogenicity due to nepafenac, despite the induction of maternal toxicity. At this dose, the animal plasma exposure to nepafenac and amfenac was approximately 260 and 2400 times human plasma exposure at the recommended human topical ophthalmic dose for rats and 80 and 680 times human plasma exposure for rabbits, respectively. In rats, maternally toxic doses ≥ 10 mg/kg were associated with dystocia , increased postimplantation loss, reduced fetal weights and growth, and reduced fetal survival.

Topical ophthalmic steroid ointment

topical ophthalmic steroid ointment

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